Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
Background DNA methylation (DNAm) is associated with gene regulation and estimated
glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more …
glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more …
[HTML][HTML] Epigenetic markers of renal function in African Americans
Chronic kidney disease (CKD) is an increasing concern in the United States due to its
rapidly rising prevalence, particularly among African Americans. Epigenetic DNA …
rapidly rising prevalence, particularly among African Americans. Epigenetic DNA …
DNA hypermethylation and DNA hypomethylation is present at different loci in chronic kidney disease
LJ Smyth, GJ McKay, AP Maxwell, AJ McKnight - Epigenetics, 2014 - Taylor & Francis
Genetic risk factors for chronic kidney disease (CKD) are being identified through
international collaborations. By comparison, epigenetic risk factors for CKD have only …
international collaborations. By comparison, epigenetic risk factors for CKD have only …
DNA methylation markers for kidney function and progression of diabetic kidney disease
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
Meta-analyses identify DNA methylation associated with kidney function and damage
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
Epigenome-wide association studies identify DNA methylation associated with kidney function
Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate
(eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to …
(eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to …
Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans
Target organ damage (TOD) manifests as vascular injuries in the body organ systems
associated with long-standing hypertension. DNA methylation in peripheral blood …
associated with long-standing hypertension. DNA methylation in peripheral blood …
DNA methylation profiling identifies epigenetic differences between early versus late stages of diabetic chronic kidney disease
A Lecamwasam, B Novakovic, B Meyer… - Nephrology dialysis …, 2021 - academic.oup.com
Background We investigated a cross-sectional epigenome-wide association study of
patients with early and late diabetes-associated chronic kidney disease (CKD) to identify …
patients with early and late diabetes-associated chronic kidney disease (CKD) to identify …
Integrated functional genomic analysis enables annotation of kidney genome-wide association study loci
KB Sieber, A Batorsky, K Siebenthall… - Journal of the …, 2019 - journals.lww.com
Background Linking genetic risk loci identified by genome-wide association studies (GWAS)
to their causal genes remains a major challenge. Disease-associated genetic variants are …
to their causal genes remains a major challenge. Disease-associated genetic variants are …
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study
Background A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to
developing diabetic kidney disease (DKD), the most common cause globally of end-stage …
developing diabetic kidney disease (DKD), the most common cause globally of end-stage …