Red blood cell omics and machine learning in transfusion medicine: singularity is near

A D'Alessandro - Transfusion Medicine and Hemotherapy, 2023 - karger.com
Background: Blood transfusion is a life-saving intervention for millions of recipients
worldwide. Over the last 15 years, the advent of high-throughput, affordable omics …

Banking with precision: transfusion medicine as a potential universal application in clinical genomics

C Montemayor, PAR Brunker… - Current opinion in …, 2019 - journals.lww.com
Banking with precision: transfusion medicine as a potential... : Current Opinion in
Hematology Banking with precision: transfusion medicine as a potential universal …

Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine

Z Isiksacan, A D'Alessandro, SM Wolf… - Proceedings of the …, 2023 - National Acad Sciences
Transfusion of red blood cells (RBCs) is one of the most valuable and widespread
treatments in modern medicine. Lifesaving RBC transfusions are facilitated by the cold …

Red blood cell storage: from genome to exposome towards personalized transfusion medicine

A D'Alessandro, EA Hod - Transfusion Medicine Reviews, 2023 - Elsevier
Over the last decade, the introduction of omics technologies–especially high-throughput
genomics and metabolomics–has contributed significantly to our understanding of the role of …

Metabolomics in transfusion medicine

T Nemkov, KC Hansen, LJ Dumont… - Transfusion, 2016 - Wiley Online Library
Biochemical investigations on the regulatory mechanisms of red blood cell (RBC) and
platelet (PLT) metabolism have fostered a century of advances in the field of transfusion …

[HTML][HTML] Modeling Red Blood Cell Metabolism in the Omics Era

A Key, Z Haiman, BO Palsson, A D'Alessandro - Metabolites, 2023 - mdpi.com
Red blood cells (RBCs) are abundant (more than 80% of the total cells in the human body),
yet relatively simple, as they lack nuclei and organelles, including mitochondria. Since the …

[HTML][HTML] Red blood cell proteomics update: is there more to discover?

A D'Alessandro, M Dzieciatkowska, T Nemkov… - Blood …, 2017 - ncbi.nlm.nih.gov
A great deal of interest has been attracted by backof-the-envelope calculations suggesting
that bacterial cells (recently revised to be~ 3.9× 1013) outnumber the total number of host …

[HTML][HTML] Red blood cell deformability during storage: towards functional proteomics and metabolomics in the Blood Bank

JCA Cluitmans, MR Hardeman, S Dinkla… - Blood …, 2012 - ncbi.nlm.nih.gov
During storage, RBCs undergo various metabolic, structural and morphological changes,
the so-called storage lesions1. The acceptable extent of the metabolic changes forms a …

Genomics and blood substitutes for 21st century Europe (“EuroBloodSubstitutes”)

KC Lowe - Artificial cells, blood substitutes, and biotechnology, 2006 - Taylor & Francis
Blood transfusion is a medical intervention practised throughout the world. Blood is a
biologically active material that can transmit diseases (eg, HIV/AIDS and, perhaps, v CJD) …

Proceedings of the 2022 NHLBI and OASH state of the science in transfusion medicine symposium

B Custer, EM Bloch, BJ Bryant, A D'Alessandro… - …, 2023 - Wiley Online Library
Abstract Background State of the Science (SoS) meetings are used to define and highlight
important unanswered scientific questions. The National Heart, Lung, and Blood Institute …