Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease. Due to
its long clinical course and lack of an effective treatment, AD has become a major public …

Alzheimer's disease (AD) is a disabling neurodegenerative disorder that leads to long-term
functional and cognitive impairment and greatly reduces life expectancy. Early genetic …

Since the 1990s, the genetics of Alzheimer disease (AD) has been an active area of
research. The identification of deterministic mutations in the APP, PSEN1, and PSEN2 …

Advances in genetic and genomic technologies over the last thirty years have greatly
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …

Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most
common form of dementia in elderly people. It is an emerging public health problem that …

The search for the genetic factors contributing to Alzheimer disease (AD) has evolved
tremendously throughout the years. It started from the discovery of fully penetrant mutations …

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. Fully
penetrant (causal) mutations leading to predominantly early-onset familial AD have been …

Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly and
represents an important and increasing clinical challenge in terms of diagnosis and …

Family history is the second strongest risk factor for Alzheimer disease (AD) following
advanced age. Twin and family studies indicate that genetic factors are estimated to play a …

Genetic factors play a major role in determining a person's risk to develop Alzheimer's
disease (AD). Rare mutations transmitted in a Mendelian fashion within affected families, for …