[HTML][HTML] Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders
X Yao, JT Glessner, J Li, X Qi, X Hou, C Zhu… - Translational …, 2021 - nature.com
Neuropsychiatric disorders, such as autism spectrum disorder (ASD), attention deficit
hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major …
hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major …
[HTML][HTML] Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice
JL Doherty, MJ Owen - Genome medicine, 2014 - Springer
Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …
Synaptic and brain-expressed gene sets relate to the shared genetic risk across five psychiatric disorders
AR Hammerschlag, CA de Leeuw… - Psychological …, 2020 - cambridge.org
BackgroundMounting evidence shows genetic overlap between multiple psychiatric
disorders. However, the biological underpinnings of shared risk for psychiatric disorders are …
disorders. However, the biological underpinnings of shared risk for psychiatric disorders are …
[HTML][HTML] Neuroinformatic analyses of common and distinct genetic components associated with major neuropsychiatric disorders
Major neuropsychiatric disorders are highly heritable, with mounting evidence suggesting
that these disorders share overlapping sets of molecular and cellular underpinnings. In the …
that these disorders share overlapping sets of molecular and cellular underpinnings. In the …
[PDF][PDF] Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
Examining the shared etiology of psychopathology with genome-wide association studies
TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
Classifying major mental disorders genetically
H Cao, J Wang, A Baranova, F Zhang - Progress in Neuro …, 2022 - Elsevier
Typically, mental disorders are defined and classified based on clinical symptoms and
syndromes. Although clinically useful, current diagnostic systems for psychiatry cause …
syndromes. Although clinically useful, current diagnostic systems for psychiatry cause …
Heterogeneity and polygenicity in psychiatric disorders: a genome-wide perspective
Genome-wide association studies (GWAS) have been performed for many psychiatric
disorders and revealed a complex polygenic architecture linking mental and physical health …
disorders and revealed a complex polygenic architecture linking mental and physical health …
[HTML][HTML] A structural brain network of genetic vulnerability to psychiatric illness
Psychiatry is undergoing a paradigm shift from the acceptance of distinct diagnoses to a
representation of psychiatric illness that crosses diagnostic boundaries. How this transition …
representation of psychiatric illness that crosses diagnostic boundaries. How this transition …
Gene-based analyses reveal novel genetic overlap and allelic heterogeneity across five major psychiatric disorders
Studies using genome-wide association (GWA) single nucleotide polymorphism (SNP) level
data have indicated genetic overlap across the five major disorders in the Psychiatric …
data have indicated genetic overlap across the five major disorders in the Psychiatric …