Background C-type natriuretic peptide (CNP) is a known target for promoting growth and has
been implicated as a therapeutic opportunity for the prevention and treatment of …

Background—The primary role of natriuretic peptide receptor-3 (NPR3) or NPR-C is in the
clearance of natriuretic peptides that play an important role in modulating intravascular …

Objective Abnormalities in the natriuretic peptide system could play a key role in the genesis
of hypertension. We evaluated the associations between a family history of hypertension …

Elevated blood pressure (BP) is a major global risk factor for cardiovascular disease.
Genome-wide association studies have identified several genetic variants at the NPR3 locus …

BACKGROUND: NPR3, located on human chromosome 5 (5p14–p13), encodes the
natriuretic peptide receptor type C (NPR-C) that is mainly known as the natriuretic peptide …

Background: Human genetic variation in the NPR1 (natriuretic peptide receptor 1 gene,
encoding NPR-A, atrial natriuretic peptide receptor 1) was recently shown to affect blood …

Polymorphisms within individual natriuretic peptide genes have been associated with risk
factors for cardiovascular disease, but their association with clinical outcomes was …

OBJECTIVE Hypertension in diabetes is characterized by abnormal sodium homeostasis,
suggesting a particular role of natriuretic peptide pathway. Natriuretic peptides can affect …

Northwestern Europeans are among the tallest of human populations. The increase in body
height in these people appears to have reached a plateau, suggesting the ubiquitous …

The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing
factors that regulate local blood flow, systemic blood pressure, and the reactivity of …