Understanding the genetic architecture of host proteins interacting with SARS-CoV-2 or
mediating the maladaptive host response to COVID-19 can help to identify new or repurpose …

As of July 2021, the outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-
CoV-2, has led to more than 200 million infections and more than 4.2 million deaths globally …

In the absence of effective treatment, COVID-19 is likely to remain a global disease burden.
Compounding this threat is the near certainty that novel coronaviruses with pandemic …

Human infection with SARS-CoV-2, the causative agent of COVID-19, leads to a remarkably
diverse spectrum of outcomes, ranging from asymptomatic to fatal. Recent reports suggest …

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype
that we have previously shown to be highly efficient for discovery of genetic associations …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic, responsible for millions of deaths globally. Even with effective vaccines, SARS …

The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic,
demonstrates significant interindividual variability. In addition to showing more disease in …

An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19
respiratory disease, has infected over 290,000 people since the end of 2019, killed over …

Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity
to efficiently design therapies for emerging virus variants remains an urgent challenge of the …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produced diverse
molecular variants during its recent expansion in humans that caused different …