Genetic architecture of schizophrenia: a review of major advancements

SE Legge, ML Santoro, S Periyasamy… - Psychological …, 2021 - cambridge.org
Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …

[HTML][HTML] Genetics of schizophrenia: overview of methods, findings and limitations

MG Henriksen, J Nordgaard… - Frontiers in human …, 2017 - frontiersin.org
Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular
genetic research has produced novel findings, infusing optimism about discovering the …

[HTML][HTML] Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?

J Hall, NJ Bray - Biological Psychiatry, 2022 - Elsevier
Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …

Genetics of schizophrenia

I Escudero, M Johnstone - Current psychiatry reports, 2014 - Springer
The genetic basis of schizophrenia has been a hotly debated research topic for decades, yet
recent studies, especially in the past year, have confirmed genetics as the major cause of …

[HTML][HTML] Genetics of schizophrenia

E Rees, MC O'Donovan, MJ Owen - Current Opinion in Behavioral …, 2015 - Elsevier
Highlights•The genetic liability of schizophrenia is established as polygenic.•Schizophrenia
risk alleles converge onto specific synaptic gene-sets.•Schizophrenia shares risk alleles with …

Genetics of schizophrenia: ready to translate?

C Foley, A Corvin, S Nakagome - Current psychiatry reports, 2017 - Springer
Abstract Purpose of Review This is an era where we have significantly advanced the
understanding of the genetic architecture of schizophrenia. In this review, we consider how …

Genetics of schizophrenia: new findings and challenges

PV Gejman, AR Sanders… - Annual review of …, 2011 - annualreviews.org
The work conducted using genome-wide approaches during the past several years has
invigorated the field, and represents the dawn of molecular genetics of schizophrenia. The …

[HTML][HTML] Genomic findings in schizophrenia and their implications

MJ Owen, SE Legge, E Rees, JTR Walters… - Molecular …, 2023 - nature.com
There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …

[PDF][PDF] Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions

SB Thyme, LM Pieper, EH Li, S Pandey, Y Wang… - Cell, 2019 - cell.com
Genomic studies have identified hundreds of candidate genes near loci associated with risk
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …

Genetics of schizophrenia: historical insights and prevailing evidence

J Van de Leemput, JL Hess, SJ Glatt, MT Tsuang - Advances in genetics, 2016 - Elsevier
Abstract Schizophrenia's (SZ's) heritability and familial transmission have been known for
several decades; however, despite the clear evidence for a genetic component, it has been …