Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis
We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
Exploring the genetic overlap between twelve psychiatric disorders
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation
Objective: Mental disorders are heritable and polygenic, and genome-wide genetic
correlations (rg) have indicated widespread shared genetic risk across multiple disorders …
correlations (rg) have indicated widespread shared genetic risk across multiple disorders …
Emerging phenotyping strategies will advance our understanding of psychiatric genetics
S Sanchez-Roige, AA Palmer - Nature neuroscience, 2020 - nature.com
Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …
identified numerous significant loci. Whereas these studies initially depended on cohorts …
Assessing the evidence for shared genetic risks across psychiatric disorders and traits
Genetic influences play a significant role in risk for psychiatric disorders, prompting
numerous endeavors to further understand their underlying genetic architecture. In this …
numerous endeavors to further understand their underlying genetic architecture. In this …
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …
variation is unique to individual disorders or shared across disorders is unclear. To examine …
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
B Devlin, JR Kelsoe, P Sklar, MJ Daly, MC O'Donovan… - Nature …, 2013 - nature.com
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …
variation is unique to individual disorders or shared across disorders is unclear. To examine …
Ten challenges for clinical translation in psychiatric genetics
Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …
underlying psychiatric disorders and provided important biological insights into disease …
[HTML][HTML] Translating insights from neuropsychiatric genetics and genomics for precision psychiatry
The primary aim of precision medicine is to tailor healthcare more closely to the needs of
individual patients. This requires progress in two areas: the development of more precise …
individual patients. This requires progress in two areas: the development of more precise …
Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses
In this article, we review some of the data that contribute to our understanding of the genetic
architecture of psychiatric disorders. These include results from evolutionary modelling …
architecture of psychiatric disorders. These include results from evolutionary modelling …