De novo mutations in schizophrenia implicate synaptic networks

M Fromer, AJ Pocklington, DH Kavanagh, HJ Williams… - Nature, 2014 - nature.com
Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Indonesia Schizophrenia Consortium… - Nature, 2022 - research.vu.nl
Schizophrenia has a heritability of 60-80% 1, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

V Trubetskoy, AF Pardiñas, T Qi, G Panagiotaropoulou… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80%, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

A polygenic burden of rare disruptive mutations in schizophrenia

SM Purcell, JL Moran, M Fromer, D Ruderfer… - Nature, 2014 - nature.com
Schizophrenia is a common disease with a complex aetiology, probably involving multiple
and heterogeneous genetic factors. Here, by analysing the exome sequences of 2,536 …

Puzzling over schizophrenia: schizophrenia as a pathway disease

PF Sullivan - Nature medicine, 2012 - nature.com
Effective treatment for schizophrenia is still an unmet clinical need. Alleviating problems
associated with cognitive impairment and finding the root of the disease remain priorities for …

Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia

T Sigurdsson, KL Stark, M Karayiorgou, JA Gogos… - Nature, 2010 - nature.com
Abnormalities in functional connectivity between brain areas have been postulated as an
important pathophysiological mechanism underlying schizophrenia,. In particular …

Genesis of a complex disease

J Flint, M Munafo - Nature, 2014 - nature.com
Genesis of a complex disease | Nature Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …

Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia

T Walsh, JM McClellan, SE McCarthy, AM Addington… - science, 2008 - science.org
Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences
remain elusive. We hypothesize that individually rare structural variants contribute to the …

[引用][C] Splitting schizophrenia

ES Lander - Nature, 1988 - nature.com
Splitting schizophrenia Page 1 © 1988 Nature Publishing Group _N_A_T_ll_R_E_V_(_)l_ ..
_.1_.IC_, _111_N_(_JV_E_.M_B_E_"R_llJ_H_K _ _ _ _ _ _ NEWS AND VIEWS------------------I_OS …

Common variants conferring risk of schizophrenia

H Stefansson, RA Ophoff, S Steinberg, OA Andreassen… - Nature, 2009 - nature.com
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …