Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is
associated with severe clinical endpoints. In contrast to cross-sectionally assessed …

Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-
decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci …

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

With increasing incidence and a prev-alence of> 10% among adults worldwide, chronic
kidney disease (CKD) represents a major public health issue. 1 CKD can lead to metabolic …

Chronic kidney disease (CKD) is common, affecting about 10% of the general population,
and causing significant morbidity and mortality. Apart from the risk conferred by traditional …

Genome-wide association studies (GWASs) have identified multiple loci associated with
cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time …

Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …

Many common genetic variants identified by genome-wide association studies for complex
traits map to genes previously linked to rare inherited Mendelian disorders. A systematic …

The past few years have seen major advances in genome-wide association studies (GWAS)
of CKD and kidney function–related traits in several areas: increases in sample size from> …

HapMap imputed genome-wide association studies (GWAS) have revealed> 50 loci at
which common variants with minor allele frequency> 5% are associated with kidney …