Shared heritability of human face and brain shape

S Naqvi, Y Sleyp, H Hoskens, K Indencleef… - Nature …, 2021 - nature.com
Evidence from model organisms and clinical genetics suggests coordination between the
developing brain and face, but the role of this link in common genetic variation remains …

Mechanisms that underlie co‐variation of the brain and face

RS Marcucio, NM Young, D Hu, B Hallgrimsson - genesis, 2011 - Wiley Online Library
The effect of the brain on the morphology of the face has long been recognized in both
evolutionary biology and clinical medicine. In this work, we describe factors that are active …

Genome-wide mapping of global-to-local genetic effects on human facial shape

P Claes, J Roosenboom, JD White, T Swigut, D Sero… - Nature …, 2018 - nature.com
Genome-wide association scans of complex multipartite traits like the human face typically
use preselected phenotypic measures. Here we report a data-driven approach to …

Insights into the genetic architecture of the human face

JD White, K Indencleef, S Naqvi, RJ Eller, H Hoskens… - Nature …, 2021 - nature.com
The human face is complex and multipartite, and characterization of its genetic architecture
remains challenging. Using a multivariate genome-wide association study meta-analysis of …

Decoding the human face: progress and challenges in understanding the genetics of craniofacial morphology

S Naqvi, H Hoskens, F Wilke… - Annual review of …, 2022 - annualreviews.org
Variations in the form of the human face, which plays a role in our individual identities and
societal interactions, have fascinated scientists and artists alike. Here, we review our current …

Novel genetic loci affecting facial shape variation in humans

Z Xiong, G Dankova, LJ Howe, MK Lee, PG Hysi… - elife, 2019 - elifesciences.org
The human face represents a combined set of highly heritable phenotypes, but knowledge
on its genetic architecture remains limited, despite the relevance for various fields. A series …

Human facial shape and size heritability and genetic correlations

JB Cole, M Manyama, JR Larson, DK Liberton… - Genetics, 2017 - academic.oup.com
The human face is an array of variable physical features that together make each of us
unique and distinguishable. Striking familial facial similarities underscore a genetic …

Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes

V Warrier, EM Stauffer, QQ Huang, EM Wigdor… - Nature …, 2023 - nature.com
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …

A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation

B Bonfante, P Faux, N Navarro, J Mendoza-Revilla… - Science …, 2021 - science.org
To characterize the genetic basis of facial features in Latin Americans, we performed a
genome-wide association study (GWAS) of more than 6000 individuals using 59 landmark …

[HTML][HTML] A genome-wide association study identifies five loci influencing facial morphology in Europeans

F Liu, F Van Der Lijn, C Schurmann, G Zhu… - 2012 - journals.plos.org
Inter-individual variation in facial shape is one of the most noticeable phenotypes in
humans, and it is clearly under genetic regulation; however, almost nothing is known about …