Humans exhibit considerable variability in their immune responses to the same immune
challenges. Such variation is widespread and affects individual and population‐level …

Humans display remarkable immune response variation when exposed to identical immune
challenges. However, our understanding of the genetic, evolutionary, and environmental …

Immune responses demonstrate a high level of intra-species variation, compensating for the
specialization capacity of pathogens. The recent advent of in-depth immune phenotyping …

The origins of diversity in human immunity | Nature Immunology Skip to main content Thank
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The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …

Innate immunity involves direct interactions between the host and microorganisms, both
pathogenic and symbiotic, so natural selection is expected to strongly influence genes …

The goal of translational medicine is to use an improved understanding of human biology to
develop new clinical approaches. Immune responses are highly variable from one person to …

Despite recent discoveries of genetic variants associated with autoimmunity and infection,
genetic control of the human immune system during homeostasis is poorly understood. We …

By developing a high-density murine immunophenotyping platform compatible with high-
throughput genetic screening, we have established profound contributions of genetics and …

Abstract The Immune Variation (ImmVar) project is one of a series of recent efforts to map
the extent of variation in immune function in healthy human subjects. The focus of our initial …