Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population

Z Zhang, H Li, H Weng, G Zhou, H Chen, G Yang… - BMC medicine, 2023 - Springer
Background A large proportion of pulmonary embolism (PE) heritability remains
unexplained, particularly among the East Asian (EAS) population. Our study aims to expand …

Pulmonary embolism and 529 human blood metabolites: genetic correlation and two-sample Mendelian randomization study

R Feng, M Lu, J Xu, F Zhang, M Yang, P Luo, K Xu… - BMC genomic data, 2022 - Springer
Background The incidence of pulmonary embolism complications in the literature ranges
from 10 to 50%, with a 0.5–10% risk of fatal pulmonary embolism. However, the biological …

[HTML][HTML] A genome‐wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24. 2 and 9q

JA Heit, SM Armasu, YW Asmann… - Journal of thrombosis …, 2012 - Elsevier
Objectives: To identify venous thromboembolism (VTE) disease‐susceptibility genes.
Patients and methods: We performed in silico genome wide association scan (GWAS) …

Novel genetic predictors of venous thromboembolism risk in African Americans

W Hernandez, ER Gamazon… - Blood, The Journal …, 2016 - ashpublications.org
Venous thromboembolism (VTE) is the third most common life-threatening cardiovascular
condition in the United States, with African Americans (AAs) having a 30% to 60% higher …

Associations between polymorphisms in coagulation-related genes and venous thromboembolism: A meta-analysis with trial sequential analysis

J Jiang, K Liu, J Zou, H Ma, H Yang, X Zhang, Y Jiao - Medicine, 2017 - journals.lww.com
Background: Recently, several studies showed that the polymorphisms in the coagulation-
related genes might be associated with venous thromboembolism (VTE); however, the …

Cross-ancestry investigation of venous thromboembolism genomic predictors

F Thibord, D Klarin, JA Brody, MH Chen, MG Levin… - Circulation, 2022 - Am Heart Assoc
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with
environmental and genetic determinants. Recent VTE genome-wide association studies …

Genetic associations of protein-coding variants in venous thromboembolism

XY He, BS Wu, L Yang, Y Guo, YT Deng, ZY Li… - Nature …, 2024 - nature.com
Previous genetic studies of venous thromboembolism (VTE) have been largely limited to
common variants, leaving the genetic determinants relatively incomplete. We performed an …

[HTML][HTML] Integrative analyses of genes about venous thromboembolism: An umbrella review of systematic reviews and meta-analyses

S Lee, CH Lee, MS Seo, JI Yoo - Medicine, 2022 - journals.lww.com
Background: In recent years, many studies have found possible links between gene
polymorphisms and venous thromboembolism (VTE). By identifying genetic risk factors …

Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism

S Lindström, LU Wang, EN Smith… - Blood, The Journal …, 2019 - ashpublications.org
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To
advance our understanding of the biology contributing to VTE, we conducted a genome …

A genome‐wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium

W Tang, M Teichert, DI Chasman, JA Heit… - Genetic …, 2013 - Wiley Online Library
Venous thromboembolism (VTE) is a common, heritable disease resulting in high rates of
hospitalization and mortality. Yet few associations between VTE and genetic variants, all in …