Epigenetic changes may fill a critical gap in our understanding of kidney disease
development, as they not only reflect metabolic changes but are also preserved and …

Chronic kidney disease (CKD) is an emerging public health priority associated with high
mortality rates and demanding treatment regimens, including life-style changes, medications …

Genetic risk factors for chronic kidney disease (CKD) are being identified through
international collaborations. By comparison, epigenetic risk factors for CKD have only …

Epigenetic changes might provide the biological explanation for the long-lasting impact of
metabolic alterations of diabetic kidney disease development. Here we examined cytosine …

DNA methylation and histone modifications determine renal programming and the
development and progression of renal disease. The identification of the way in which the …

Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate
(eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to …

We identified potential epigenetic biomarkers for chronic kidney disease progression by
comparing site-specific DNA methylation levels in more than 14,000 genes between African …

Epigenetics examines heritable changes in DNA and its associated proteins except
mutations in gene sequence. Epigenetic regulation plays fundamental roles in kidney cell …

Background We investigated a cross-sectional epigenome-wide association study of
patients with early and late diabetes-associated chronic kidney disease (CKD) to identify …

In patients with diabetes mellitus, poor metabolic control has a long-lasting impact on kidney
disease development. Epigenetic changes, including cytosine methylation, have been …