Dissecting polygenic signals from genome-wide association studies on human behaviour

A Abdellaoui, KJH Verweij - Nature Human Behaviour, 2021 - nature.com
Genome-wide association studies on human behavioural traits are producing large amounts
of polygenic signals with significant predictive power and potentially useful biological clues …

Hidden heritability due to heterogeneity across seven populations

FC Tropf, SH Lee, RM Verweij, G Stulp… - Nature human …, 2017 - nature.com
Meta-analyses of genome-wide association studies, which dominate genetic discovery, are
based on data from diverse historical time periods and populations. Genetic scores derived …

“Reports of my death were greatly exaggerated”: Behavior genetics in the postgenomic era

KP Harden - Annual Review of Psychology, 2021 - annualreviews.org
Behavior genetics studies how genetic differences among people contribute to differences in
their psychology and behavior. Here, I describe how the conclusions and methods of …

Genome wide association studies of behavior are social science

E Turkheimer - Philosophy of behavioral biology, 2011 - Springer
A recent series of papers in Nature Genetics described several combined Genome Wide
Association Studies (GWAS) of height. Although height is a highly heritable trait that can be …

Why it is hard to find genes associated with social science traits: Theoretical and empirical considerations

CF Chabris, JJ Lee, DJ Benjamin… - … journal of public …, 2013 - ajph.aphapublications.org
Objectives. We explain why traits of interest to behavioral scientists may have a genetic
architecture featuring hundreds or thousands of loci with tiny individual effects rather than a …

Replicability and robustness of genome-wide-association studies for behavioral traits

CA Rietveld, D Conley, N Eriksson… - Psychological …, 2014 - journals.sagepub.com
A recent genome-wide-association study of educational attainment identified three single-
nucleotide polymorphisms (SNPs) whose associations, despite their small effect sizes (each …

Twin studies to GWAS: there and back again

NP Friedman, MT Banich, MC Keller - Trends in cognitive sciences, 2021 - cell.com
The field of human behavioral genetics has come full circle. It began by using twin/family
studies to estimate the relative importance of genetic and environmental influences. As large …

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

AD Grotzinger, M Rhemtulla, R de Vlaming… - Nature human …, 2019 - nature.com
Genetic correlations estimated from genome-wide association studies (GWASs) reveal
pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural …

Genetic and environmental influences on behavior: capturing all the interplay.

W Johnson - Psychological review, 2007 - psycnet.apa.org
Basic quantitative genetic models of human behavioral variation have made clear that
individual differences in behavior cannot be understood without acknowledging the …

Participation bias in the UK Biobank distorts genetic associations and downstream analyses

T Schoeler, D Speed, E Porcu, N Pirastu… - Nature Human …, 2023 - nature.com
While volunteer-based studies such as the UK Biobank have become the cornerstone of
genetic epidemiology, the participating individuals are rarely representative of their target …