Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries

Z Liu, R Liu, H Gao, S Jung, X Gao, R Sun, X Liu… - Nature …, 2023 - nature.com
Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with
the following two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most …

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

JZ Liu, S Van Sommeren, H Huang, SC Ng, R Alberts… - Nature …, 2015 - nature.com
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …

[HTML][HTML] Inflammatory bowel disease: genetics, epigenetics, and pathogenesis

I Loddo, C Romano - Frontiers in immunology, 2015 - frontiersin.org
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

L Jostins, S Ripke, RK Weersma, RH Duerr… - Nature, 2012 - nature.com
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

Genetics of inflammatory bowel disease in Asia: systematic review and meta-analysis

SC Ng, KKF Tsoi, MA Kamm, B Xia, J Wu… - Inflammatory bowel …, 2012 - academic.oup.com
Background Inflammatory bowel diseases (IBD) result from an interaction between genetic
and environmental factors. Preliminary findings suggest that susceptibility genes differ …

Genome-wide association study identifies African-specific susceptibility loci in African Americans with inflammatory bowel disease

SR Brant, DT Okou, CL Simpson, DJ Cutler… - Gastroenterology, 2017 - Elsevier
Background & Aims The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and
Crohn's disease (CD) cause significant morbidity and are increasing in prevalence among …

[PDF][PDF] A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort

J Hampe, S Schreiber, SH Shaw, KF Lau… - The American journal of …, 1999 - cell.com
Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal
inflammation, typically starting in early adulthood. IBD is subdivided into two subtypes, on …

The genetic basis of inflammatory bowel disease

R Cooney, D Jewell - Digestive diseases, 2009 - karger.com
Twin studies and large-scale population studies have confirmed an increased sibling risk for
both Crohn's disease (CD) and ulcerative colitis (UC). Unlike single gene disorders, CD and …

Genetics of inflammatory bowel diseases

DPB McGovern, S Kugathasan, JH Cho - Gastroenterology, 2015 - Elsevier
In this review, we provide an update on genome-wide association studies (GWAS) in
inflammatory bowel disease (IBD). In addition, we summarize progress in defining the …

Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans

C Huang, T Haritunians, DT Okou, DJ Cutler, ME Zwick… - Gastroenterology, 2015 - Elsevier
Background & Aims Inflammatory bowel disease (IBD) has familial aggregation in African
Americans (AAs), but little is known about the molecular genetic susceptibility. Mapping …