The genetic basis of major depression

KM Kendall, E Van Assche, TFM Andlauer… - Psychological …, 2021 - cambridge.org
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …

Overview of the genetics of major depressive disorder

FW Lohoff - Current psychiatry reports, 2010 - Springer
Major depressive disorder (MDD) is a common psychiatric illness with high levels of
morbidity and mortality. Despite intensive research during the past several decades, the …

[HTML][HTML] Major depressive disorder: existing hypotheses about pathophysiological mechanisms and new genetic findings

M Kamran, F Bibi, A ur. Rehman, DW Morris - Genes, 2022 - mdpi.com
Major depressive disorder (MDD) is a common mental disorder generally characterized by
symptoms associated with mood, pleasure and effectiveness in daily life activities. MDD is …

The current state of play on the molecular genetics of depression

S Cohen-Woods, IW Craig, P McGuffin - Psychological medicine, 2013 - cambridge.org
BackgroundIt has been well established that both genes and non-shared environment
contribute substantially to the underlying aetiology of major depressive disorder (MDD). A …

[HTML][HTML] Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned

NR Wray, ML Pergadia, DHR Blackwood… - Molecular …, 2012 - nature.com
Major depressive disorder (MDD) is a common complex disorder with a partly genetic
etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 …

[HTML][HTML] The genetic basis of major depressive disorder

J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

[PDF][PDF] Uncovering the genetic architecture of major depression

AM McIntosh, PF Sullivan, CM Lewis - Neuron, 2019 - cell.com
There have been several recent studies addressing the genetic architecture of depression.
This review serves to take stock of what is known now about the genetics of depression, how …

[HTML][HTML] Genetics factors in major depression disease

M Shadrina, EA Bondarenko, PA Slominsky - Frontiers in psychiatry, 2018 - frontiersin.org
Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts

P Muglia, F Tozzi, NW Galwey, C Francks… - Molecular …, 2010 - nature.com
Major depressive disorder (MDD) is a highly prevalent disorder with substantial heritability.
Heritability has been shown to be substantial and higher in the variant of MDD characterized …

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

NR Wray, S Ripke, M Mattheisen, M Trzaskowski… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …