Comparative genetic architectures of schizophrenia in East Asian and European populations

M Lam, CY Chen, Z Li, AR Martin, J Bryois, X Ma… - Nature …, 2019 - nature.com
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

Z Li, J Chen, H Yu, L He, Y Xu, D Zhang, Q Yi, C Li… - Nature …, 2017 - nature.com
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …

[HTML][HTML] Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry

TB Bigdeli, G Genovese, P Georgakopoulos… - Molecular …, 2020 - nature.com
Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting
tens of millions of individuals worldwide. While rare genetic variants play a role in the …

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …

Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11. 2

WH Yue, HF Wang, LD Sun, FL Tang, ZH Liu… - Nature …, 2011 - nature.com
To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide
association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 …

Genome‐wide association study of schizophrenia in Ashkenazi Jews

FS Goes, J McGrath, D Avramopoulos… - American Journal of …, 2015 - Wiley Online Library
Schizophrenia is a common, clinically heterogeneous disorder associated with lifelong
morbidity and early mortality. Several genetic variants associated with schizophrenia have …

Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective

CA Dennison, SE Legge, AF Pardinas… - Schizophrenia research, 2020 - Elsevier
Genome-wide association studies (GWAS) have proved to be a powerful approach for gene
discovery in schizophrenia; their findings have important implications not just for our …

Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia

D Curtis - Psychiatric genetics, 2018 - journals.lww.com
Background The polygenic risk score (PRS) for schizophrenia, derived from very large
numbers of weakly associated genetic markers, has been repeatedly shown to be robustly …

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

AF Pardiñas, P Holmans, AJ Pocklington… - Nature …, 2018 - nature.com
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …

Accumulated environmental risk determining age at schizophrenia onset: a deep phenotyping-based study

B Stepniak, S Papiol, C Hammer, A Ramin… - The Lancet …, 2014 - thelancet.com
Background Schizophrenia is caused by a combination of genetic and environmental
factors, as first evidenced by twin studies. Extensive efforts have been made to identify the …