[HTML][HTML] Problems with using polygenic scores to select embryos

P Turley, MN Meyer, N Wang, D Cesarini… - … England Journal of …, 2021 - Mass Medical Soc
Companies have recently begun to sell a new service to patients considering in vitro
fertilization: embryo selection based on polygenic scores (ESPS). These scores represent …

Screening embryos for polygenic conditions and traits: ethical considerations for an emerging technology

G Lázaro-Muñoz, S Pereira, S Carmi, T Lencz - Genetics in Medicine, 2021 - nature.com
Polygenic embryo screening (PES)—the use of polygenic risk scores for complex
phenotypes as a component of preimplantation genetic testing (PGT)—has emerged as a …

[HTML][HTML] Utility and first clinical application of screening embryos for polygenic disease risk reduction

NR Treff, J Eccles, L Lello, E Bechor, J Hsu… - Frontiers in …, 2019 - frontiersin.org
For over 2 decades preimplantation genetic testing (PGT) has been in clinical use to reduce
the risk of miscarriage and genetic disease in patients with advanced maternal age and risk …

[HTML][HTML] The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

F Forzano, O Antonova, A Clarke, G de Wert… - European Journal of …, 2022 - nature.com
Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private
testing companies to parents using in vitro fertilisation as being useful in selecting the …

Utility of polygenic embryo screening for disease depends on the selection strategy

T Lencz, D Backenroth, E Granot-Hershkovitz, A Green… - Elife, 2021 - elifesciences.org
Polygenic risk scores (PRSs) have been offered since 2019 to screen in vitro fertilization
embryos for genetic liability to adult diseases, despite a lack of comprehensive modeling of …

[PDF][PDF] Screening human embryos for polygenic traits has limited utility

E Karavani, O Zuk, D Zeevi, N Barzilai, NC Stefanis… - Cell, 2019 - cell.com
The increasing proportion of variance in human complex traits explained by polygenic
scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of …

[HTML][HTML] Genetic testing of embryos: practices and perspectives of US in vitro fertilization clinics

S Baruch, D Kaufman, KL Hudson - Fertility and sterility, 2008 - Elsevier
OBJECTIVE: To better understand the current practices of IVF clinics regarding
preimplantation genetic diagnosis (PGD) and explore the attitudes and opinions of clinic …

Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual …

A Capalbo, M Poli, A Riera-Escamilla… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND Our genetic code is now readable, writable and hackable. The recent
escalation of genome-wide sequencing (GS) applications in population diagnostics will not …

[HTML][HTML] Use of array comparative genomic hybridization (array-CGH) for embryo assessment: clinical results

C Rubio, L Rodrigo, P Mir, E Mateu, V Peinado… - Fertility and sterility, 2013 - Elsevier
Objective To review clinical outcomes after preimplantation genetic screening. Most
methods of embryo viability assessment involve morphologic evaluation at different …

[HTML][HTML] Embryo selection with artificial intelligence: how to evaluate and compare methods?

MF Kragh, H Karstoft - Journal of assisted reproduction and genetics, 2021 - Springer
Embryo selection within in vitro fertilization (IVF) is the process of evaluating qualities of
fertilized oocytes (embryos) and selecting the best embryo (s) available within a patient …