Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …

Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …

As the size of genome-wide association studies increase, the number of associated trait loci
identified inevitably increase. One welcomes this if it allows the better delineation of the …

Alzheimer's disease (AD) has no cure, but early detection and risk prediction could allow
earlier intervention. Genetic risk factors may differ between ethnic populations. To discover …

Background Alzheimer's disease is a debilitating and highly heritable neurological
condition. As such, genetic studies have sought to understand the genetic architecture of …

A large fraction of genetic risk factors for Alzheimer's Disease (AD) is still not identified,
limiting the understanding of AD pathology and study of therapeutic targets. We conducted a …

Background Genetic studies have primarily been conducted in European ancestry
populations, identifying dozens of loci associated with late-onset Alzheimer's disease (AD) …

Importance Compared with non-Hispanic White individuals, African American individuals
from the same community are approximately twice as likely to develop Alzheimer disease …

Genome-wide association studies (GWAS) have gained considerable momentum over the
last couple of years for the identification of novel complex disease genes. In the field of …

Genome-wide association studies (GWAS) have uncovered over two dozen candidate
Alzheimer disease susceptibility genes; however, the results of these studies showed limited …