Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …

Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular
genetic research has produced novel findings, infusing optimism about discovering the …

Schizophrenia is a common multigenic and debilitating neurological disorder characterized
by chronic psychotic symptoms and psychosocial impairment. Complex interactions of …

There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …

Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Highlights•The genetic liability of schizophrenia is established as polygenic.•Schizophrenia
risk alleles converge onto specific synaptic gene-sets.•Schizophrenia shares risk alleles with …

Studies aiming to identify susceptibility genes for schizophrenia and other complex
psychiatric disorders are faced with the confounds of subjective clinical criteria, commonly …

The genetic basis of schizophrenia has been a hotly debated research topic for decades, yet
recent studies, especially in the past year, have confirmed genetics as the major cause of …

Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …