The genetic architecture of schizophrenia: review of large-scale genetic studies

H Kato, H Kimura, I Kushima, N Takahashi… - Journal of Human …, 2023 - nature.com
Schizophrenia is a complex and often chronic psychiatric disorder with high heritability.
Diagnosis of schizophrenia is still made clinically based on psychiatric symptoms; no …

Where are the missing pieces of the schizophrenia genetics puzzle?

SL Girard, L Xiong, PA Dion, GA Rouleau - Current opinion in genetics & …, 2011 - Elsevier
On the basis of recent data from candidate region/gene and genome-wide association
studies (GWAS) and their follow-up investigations, the number of genes potentially …

The genomics of schizophrenia: shortcomings and solutions

C Zhuo, W Hou, G Li, F Mao, S Li, X Lin, D Jiang… - Progress in Neuro …, 2019 - Elsevier
Due to recent advances in human genomic technologies, there have been explosive
interests and extensive research on the genomics of schizophrenia, a severe psychiatric …

Molecular genetics of schizophrenia: past, present and future

S Prasad, P Semwal, S Deshpande, T Bhatia… - Journal of …, 2002 - Springer
Schizophrenia is a severe neuropsychiatric disorder with a polygenic mode of inheritance
which is also governed by non-genetic factors. Candidate genes identified on the basis of …

[HTML][HTML] New findings in the genetics of schizophrenia

L Hosak - World journal of psychiatry, 2013 - ncbi.nlm.nih.gov
New findings in schizophrenia genetics are based on genome-wide association studies
(GWAS), research into DNA copy number variations (CNVs), and endophenotypes. More …

Genetics of schizophrenia: ready to translate?

C Foley, A Corvin, S Nakagome - Current psychiatry reports, 2017 - Springer
Abstract Purpose of Review This is an era where we have significantly advanced the
understanding of the genetic architecture of schizophrenia. In this review, we consider how …

Genetics of schizophrenia: new findings and challenges

PV Gejman, AR Sanders… - Annual review of …, 2011 - annualreviews.org
The work conducted using genome-wide approaches during the past several years has
invigorated the field, and represents the dawn of molecular genetics of schizophrenia. The …

Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics

I Giegling, L Hosak, R Mössner, A Serretti… - The world journal of …, 2017 - Taylor & Francis
Objectives: Schizophrenia is a severe psychiatric disease affecting about 1% of the general
population. The relative contribution of genetic factors has been estimated to be up to 80 …

Transcriptome study of differential expression in schizophrenia

AR Sanders, HHH Göring, J Duan… - Human molecular …, 2013 - academic.oup.com
Schizophrenia genome-wide association studies (GWAS) have identified common SNPs,
rare copy number variants (CNVs) and a large polygenic contribution to illness risk, but …

Genome sequencing broadens the range of contributing variants with clinical implications in schizophrenia

BA Mojarad, Y Yin, R Manshaei, I Backstrom… - Translational …, 2021 - nature.com
The range of genetic variation with potential clinical implications in schizophrenia, beyond
rare copy number variants (CNVs), remains uncertain. We therefore analyzed genome …