Neutrophils: from IBD to the gut microbiota

C Danne, J Skerniskyte, B Marteyn… - Nature Reviews …, 2024 - nature.com
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal
tract that results from dysfunction in innate and/or adaptive immune responses. Impaired …

Neutrophil–T cell crosstalk in inflammatory bowel disease

E Kvedaraite - Immunology, 2021 - Wiley Online Library
Neutrophils are the most abundant leucocytes in human blood, promptly recruited to the site
of tissue injury, where they orchestrate inflammation and tissue repair. The multifaceted …

Dichotomous roles of neutrophils in modulating pathogenic and repair processes of inflammatory bowel diseases

H Chen, X Wu, C Xu, J Lin, Z Liu - Precision Clinical Medicine, 2021 - academic.oup.com
Neutrophils are considered as complex innate immune cells and play a critical role in
maintaining intestinal mucosal homeostasis. They exert robust pro-inflammatory effects and …

[HTML][HTML] Neutrophils in intestinal inflammation: what we know and what we could expect for the near future

L Arosa, M Camba-Gómez, J Conde-Aranda - Gastrointestinal Disorders, 2022 - mdpi.com
Neutrophils are short-lived cells that play a crucial role in inflammation. As in other tissues,
these polymorphonuclear phagocytes are involved in the intestinal inflammatory response …

[HTML][HTML] The dual role of neutrophils in inflammatory bowel diseases

O Wéra, P Lancellotti, C Oury - Journal of clinical medicine, 2016 - mdpi.com
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are
characterised by aberrant immunological responses leading to chronic inflammation without …

Potential roles of neutrophils in regulating intestinal mucosal inflammation of inflammatory bowel disease

GX Zhou, ZJ Liu - Journal of digestive diseases, 2017 - Wiley Online Library
Inflammatory bowel diseases (IBD), comprising of ulcerative colitis and Crohn's disease, are
inflammatory disorders of the gastrointestinal tract characterized by chronically relapsing …

[HTML][HTML] The role of neutrophils during intestinal inflammation

BM Fournier, CA Parkos - Mucosal immunology, 2012 - Elsevier
Polymorphonuclear leukocytes or neutrophils play a critical role in the maintenance of
intestinal homeostasis. They have elegant defense mechanisms to eliminate microbes that …

The interplay between microbes and the immune response in inflammatory bowel disease

A Goethel, K Croitoru, DJ Philpott - The Journal of physiology, 2018 - Wiley Online Library
The aetiology and pathogenesis of inflammatory bowel disease (IBD) remains unclear but
involves a complex interplay between genetic risk, environmental exposures, the immune …

Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps

L Vong, RJ Lorentz, A Assa, M Glogauer… - The Journal of …, 2014 - journals.aai.org
Neutrophil extracellular traps (NETs) are an essential component of the antimicrobial
repertoire and represent an effective means by which neutrophils capture, contain, and kill …

Colonic neutrophils in inflammatory bowel disease: double-edged swords of the innate immune system with protective and destructive capacity

IR Williams, CA Parkos - Gastroenterology, 2007 - gastrojournal.org
Several forms of active inflammatory bowel disease (IBD) feature the presence of a mixed
inflammatory infiltrate that includes neutrophils. A large influx of neutrophils can lead to the …