Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease

H Liu, T Doke, D Guo, X Sheng, Z Ma, J Park, HMT Vy… - Nature …, 2022 - nature.com
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …

New loci associated with kidney function and chronic kidney disease

A Köttgen, C Pattaro, CA Böger, C Fuchsberger… - Nature …, 2010 - nature.com
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic
studies have identified common CKD susceptibility variants. The CKDGen consortium …

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

X Sheng, Y Guan, Z Ma, J Wu, H Liu, C Qiu, S Vitale… - Nature …, 2021 - nature.com
The functional interpretation of genome-wide association studies (GWAS) is challenging due
to the cell-type-dependent influences of genetic variants. Here, we generated …

Unravelling the complex genetics of common kidney diseases: from variants to mechanisms

KM Sullivan, K Susztak - Nature Reviews Nephrology, 2020 - nature.com
Genome-wide association studies (GWAS) have identified hundreds of loci associated with
kidney-related traits such as glomerular filtration rate, albuminuria, hypertension, electrolyte …

Discovery and prioritization of variants and genes for kidney function in> 1.2 million individuals

KJ Stanzick, Y Li, P Schlosser, M Gorski… - Nature …, 2021 - nature.com
Genes underneath signals from genome-wide association studies (GWAS) for kidney
function are promising targets for functional studies, but prioritizing variants and genes is …

A catalog of genetic loci associated with kidney function from analyses of a million individuals

M Wuttke, Y Li, M Li, KB Sieber, MF Feitosa, M Gorski… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

Insights into kidney diseases from genome-wide association studies

M Wuttke, A Köttgen - Nature Reviews Nephrology, 2016 - nature.com
Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …

[PDF][PDF] Genetic-variation-driven gene-expression changes highlight genes with important functions for kidney disease

YA Ko, H Yi, C Qiu, S Huang, J Park, N Ledo… - The American Journal of …, 2017 - cell.com
Chronic kidney disease (CKD) is a complex gene-environmental disease affecting close to
10% of the US population. Genome-wide association studies (GWASs) have identified …

Genetic and epigenetic factors influencing chronic kidney disease

LJ Smyth, S Duffy, AP Maxwell… - American Journal of …, 2014 - journals.physiology.org
Chronic kidney disease (CKD) has become a serious public health problem because of its
associated morbidity, premature mortality, and attendant healthcare costs. The rising …

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

AP Morris, TH Le, H Wu, A Akbarov… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD) affects~ 10% of the global population, with considerable
ethnic differences in prevalence and aetiology. We assemble genome-wide association …