Meta-analysis is pervasively used to combine multiple genome-wide association studies
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …

Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental
conditions characterized by early childhood-onset impairments in communication and social …

Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …

Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …

Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …

The substantial phenotypic heterogeneity in autism limits our understanding of its genetic
etiology. To address this gap, here we investigated genetic differences between autistic …

Personality and cognitive function are heritable mental traits whose genetic foundations may
be distributed across interconnected brain functions. Previous studies have typically treated …

Background Sex differences in incidence and/or presentation of schizophrenia (SCZ), major
depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for …

Importance Schizophrenia is a clinically heterogeneous disorder. It is currently unclear how
variability in symptom dimensions and cognitive ability is associated with genetic liability for …

Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level,
and the aim is to use them as biomarkers of disease and poor outcomes in real-world …