In the field of transfusion medicine, the clinical relevance of the metabolic markers of the red
blood cell (RBC) storage lesion is incompletely understood. Here, we performed …

Genome-wide association analyses using high-throughput metabolomics platforms have led
to novel insights into the biology of human metabolism,,,,,–. This detailed knowledge of the …

Recently, four studies on the potential value of small-molecule metabolites by
highthroughput functional metabolomics were published in Nature Medicine (Buergel et al …

Natural human knockouts of genes associated with desirable outcomes, such as PCSK9
with low levels of LDL-cholesterol, can lead to the discovery of new drug targets and …

Background: Idiopathic pulmonary fibrosis (IPF) is caused by aberrant repair because of
alveolar epithelial injury and can only be effectively treated with several compounds …

Inborn errors of metabolism (IEMs) are a group of more than 1000 inherited diseases that
are individually rare but have a cumulative global prevalence of 50 per 100,000 births …

Background Selective fetal growth restriction (sFGR) is an extreme complication that
significantly increases the risk of perinatal mortality and long-term adverse neurological …

Background Acetaminophen (APAP) is the most common cause liver injury following alcohol
in US patients. Predicting liver injury and subsequent hepatic regeneration in patients taking …

Background Common and rare variants contribute to the etiology of complex traits. However,
the extent to which the phenotypic effects of common and rare variants involve shared …

In Nature Medicine, Surendran and colleagues recently reported the analysis of human
plasma metabolomic data for 913 metabolites in∼ 20,000 individuals, identifying 2,599 …