Intestinal epithelial pH-sensing receptor GPR65 maintains mucosal homeostasis via regulating antimicrobial defense and restrains gut inflammation in inflammatory …

G Li, J Lin, X Gao, H Su, R Lin, H Gao, Z Feng, H Wu… - Gut …, 2023 - Taylor & Francis
Intestinal epithelial cell (IEC) regulation of barrier function and mucosal homeostasis
enables the establishment of a harmonious gut microenvironment. However, host-derived …

Human leukocyte antigen signatures as pathophysiological discriminants of microscopic colitis subtypes

T Zheng, G Roda, Y Zabana… - Journal of Crohn's …, 2024 - academic.oup.com
Abstract Background and Aims Microscopic colitis [MC] is currently regarded as an
inflammatory bowel disease that manifests as two subtypes: collagenous colitis [CC] and …

Potential shared pathogenic mechanisms between endometriosis and inflammatory bowel disease indicate a strong initial effect of immune factors

H Zhang, Y Mo, L Wang, H Zhang, S Wu… - Frontiers in …, 2024 - frontiersin.org
Introduction Over the past decades, immune dysregulation has been consistently
demonstrated being common charactoristics of endometriosis (EM) and Inflammatory Bowel …

Transcriptome-wide association studies associated with Crohn's disease: challenges and perspectives

K Jia, J Shen - Cell & Bioscience, 2024 - Springer
Crohn's disease (CD) is regarded as a lifelong progressive disease affecting all segments of
the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) …

Schisandra chinensis Bee Pollen Ameliorates Colitis in Mice by Modulating Gut Microbiota and Regulating Treg/Th17 Balance

N Cheng, X Wang, Y Zhou, X Zhao, M Chen, H Zhao… - Foods, 2024 - mdpi.com
Colitis is a chronic disease associated with alterations in the composition of gut microbiota.
Schisandra chinensis bee pollen extract (SCPE) has been proved to be rich in phenolic …

Association between inflammatory bowel disease and cancer risk: evidence triangulation from genetic correlation, Mendelian randomization, and colocalization …

D Liu, M Cao, H Wang, W Cao, C Zheng, Y Li, Y Wang - BMC medicine, 2024 - Springer
Background Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and
ulcerative colitis (UC), has been associated with several cancer risks in observational …

Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study

M Makuuchi, Y Kakuta, J Umeno, T Fujii… - Journal of …, 2024 - Springer
Background This study evaluated the effectiveness of NUDT15 codon 139 genotyping in
optimizing thiopurine treatment for inflammatory bowel disease (IBD) in Japan, using real …

The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease

R Tyebally, A Xue, JE Powell - Clinical and Translational …, 2023 - Wiley Online Library
Complex diseases are heterogenous due to variation in their genetic and environmental
underpinnings, leading to varied treatment responses. Genome‐wide association studies …

A review of disease risk prediction methods and applications in the omics era

C Sun, X Cheng, J Xu, H Chen, J Tao, Y Dong… - …, 2024 - Wiley Online Library
Risk prediction and disease prevention are the innovative care challenges of the 21st
century. Apart from freeing the individual from the pain of disease, it will lead to low medical …

Precision medicine in inflammatory bowel disease

Z Zeng, M Jiang, X Li, J Yuan… - Precision Clinical …, 2023 - academic.oup.com
Inflammatory bowel disease (IBD) is an incurable disease characterized by remission-
relapse cycles throughout its course. Both Crohn's disease (CD) and ulcerative colitis (UC) …