Genetics of 35 blood and urine biomarkers in the UK Biobank
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
[HTML][HTML] Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
Mechanisms of cognitive dysfunction in CKD
Cognitive impairment is an increasingly recognized major cause of chronic disability and is
commonly found in patients with chronic kidney disease (CKD). Knowledge of the …
commonly found in patients with chronic kidney disease (CKD). Knowledge of the …
Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning
Cardiometabolic diseases are an increasing global health burden. While socioeconomic,
environmental, behavioural, and genetic risk factors have been identified, a better …
environmental, behavioural, and genetic risk factors have been identified, a better …
[HTML][HTML] Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression
The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
[HTML][HTML] Kidney damage causally affects the brain cortical structure: a Mendelian randomization study
X Chen, J Kong, J Pan, K Huang, W Zhou, X Diao… - …, 2021 - thelancet.com
Background Alterations in the brain cortical structures of patients with chronic kidney
disease (CKD) have been reported; however, the cause has not been determined yet …
disease (CKD) have been reported; however, the cause has not been determined yet …
[HTML][HTML] Discovery and prioritization of variants and genes for kidney function in> 1.2 million individuals
KJ Stanzick, Y Li, P Schlosser, M Gorski… - Nature …, 2021 - nature.com
Genes underneath signals from genome-wide association studies (GWAS) for kidney
function are promising targets for functional studies, but prioritizing variants and genes is …
function are promising targets for functional studies, but prioritizing variants and genes is …
Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation
We conduct high coverage (> 30×) whole-genome sequencing of 180 individuals from 12
indigenous African populations. We identify millions of unreported variants, many predicted …
indigenous African populations. We identify millions of unreported variants, many predicted …
[HTML][HTML] Heart disease and stroke statistics-2021 update: a report from the American Heart Association.
Background The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …
[HTML][HTML] Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease
AF Schmidt, NB Hunt, M Gordillo-Marañón… - Nature …, 2021 - nature.com
Abstract Development of cholesteryl ester transfer protein (CETP) inhibitors for coronary
heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from …
heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from …