Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

Understanding functional effects of genetic variants is one of the key challenges in human
genetics, as much of disease-associated variation is located in non-coding regions with …

Human DNA present in faecal samples can result in a small number of human reads in gut
shotgun metagenomic sequencing data. However, it is presently unclear how much …

Studies of the human microbiome share both technical and conceptual similarities with
genome-wide association studies and genetic epidemiology. However, the microbiome has …

Interindividual variability in genes encoding drug-metabolizing enzymes, transporters,
receptors, and human leukocyte antigens has a major impact on a patient's response to …

Microbial consortia exhibit complex functional properties in contexts ranging from soils to
bioreactors to human hosts. Understanding how community composition determines …

Many methods have been developed to leverage expression quantitative trait loci (eQTL)
data to nominate candidate genes from genome-wide association studies. These methods …

Background Genetic influences are ubiquitous as virtually all phenotypes and most
exposures typically classified as environmental have been found to be heritable. A …