A genome-wide search identifies potential new susceptibility loci for Crohn's disease

Y Ma, JD Ohmen, Z Li, GL Bentley… - Inflammatory bowel …, 1999 - academic.oup.com
Chronic inflammatory bowel disease (IBD) presents as two major clinical forms, Crohn's
disease (CD) and ulcerative colitis (UC). Genetic epidemiological studies and animal …

Genetics of ulcerative colitis

AI Thompson, CW Lees - Inflammatory bowel diseases, 2011 - academic.oup.com
Ulcerative colitis (UC) and Crohn's disease (CD) are related polygenic inflammatory bowel
diseases (IBDs), with distinct and overlapping susceptibility loci. Recently, hypothesis-free …

Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics

NT Ventham, NA Kennedy, ER Nimmo, J Satsangi - Gastroenterology, 2013 - Elsevier
In the past decade, there have been fundamental advances in our understanding of genetic
factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and …

[PDF][PDF] Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci

JD Rioux, MS Silverberg, MJ Daly, AH Steinhart… - The American Journal of …, 2000 - cell.com
The chronic inflammatory bowel diseases (IBDs)—Crohn disease (CD) and ulcerative colitis
(UC)—are idiopathic, inflammatory disorders of the gastrointestinal tract. These conditions …

Using a genome-wide scan and meta-analysis to identify a novel IBD locus and confirm previously identified IBD loci

CN Williams, K Kocher, ES Lander… - Inflammatory bowel …, 2002 - academic.oup.com
Seven loci that potentially confer susceptibility to inflammatory bowel disease (IBD) or one of
its subtypes have been identified to date; however, most are unconfirmed, and the complete …

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

A Franke, T Balschun, TH Karlsen, J Sventoraityte… - Nature …, 2008 - nature.com
Inflammatory bowel disease (IBD) typically manifests as either ulcerative colitis (UC) or
Crohn's disease (CD). Systematic identification of susceptibility genes for IBD has thus far …

Genetic studies of inflammatory bowel disease-focusing on Asian patients

SC Park, YT Jeen - Cells, 2019 - mdpi.com
The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however,
increased and persistent intestinal inflammation, due to inappropriate immune responses …

Common variants at five new loci associated with early-onset inflammatory bowel disease

M Imielinski, RN Baldassano, A Griffiths, RK Russell… - Nature …, 2009 - nature.com
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common
causes of morbidity in children and young adults in the western world. Here we report the …

Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort

RK Weersma, PCF Stokkers, I Cleynen… - Official journal of the …, 2009 - journals.lww.com
OBJECTIVES: Inflammatory bowel diseases (IBD)—Crohn's disease (CD) and ulcerative
colitis (UC)—are chronic gastrointestinal inflammatory disorders with a complex genetic …

Fine-mapping inflammatory bowel disease loci to single-variant resolution

H Huang, M Fang, L Jostins, M Umićević Mirkov… - Nature, 2017 - nature.com
Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect
millions of people worldwide. Genome-wide association studies have identified 200 …