Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
The impact of rare protein coding genetic variation on adult cognitive function
Compelling evidence suggests that human cognitive function is strongly influenced by
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …
Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders
There is a long-standing interest in exploring the relationship between blood-based
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …
Genetic heterogeneity and subtypes of major depression
Major depression (MD) is a heterogeneous disorder; however, the extent to which genetic
factors distinguish MD patient subgroups (genetic heterogeneity) remains uncertain. This …
factors distinguish MD patient subgroups (genetic heterogeneity) remains uncertain. This …
Polygenic risk for depression, anxiety and neuroticism are associated with the severity and rate of change in depressive symptoms across adolescence
Background Adolescence marks a period where depression will commonly onset. Twin
studies show that genetic influences play a role in how depression develops and changes …
studies show that genetic influences play a role in how depression develops and changes …
Impaired regulatory T cell control of astroglial overdrive and microglial pruning in schizophrenia
F Corsi-Zuelli, B Deakin - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
It is widely held that schizophrenia involves an active process of peripheral inflammation that
induces or reflects brain inflammation with activation of microglia, the brain's resident …
induces or reflects brain inflammation with activation of microglia, the brain's resident …
[HTML][HTML] Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?
J Hall, NJ Bray - Biological Psychiatry, 2022 - Elsevier
Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …
conferring risk to the disorder. This progress offers an important route toward defining the …
Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance
SC Page, SR Sripathy, F Farinelli… - Proceedings of the …, 2022 - National Acad Sciences
Neurons derived from human induced pluripotent stem cells (hiPSCs) have been used to
model basic cellular aspects of neuropsychiatric disorders, but the relationship between the …
model basic cellular aspects of neuropsychiatric disorders, but the relationship between the …
Grey and white matter microstructure is associated with polygenic risk for schizophrenia
Recent discovery of approximately 270 common genetic variants associated with
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
Massively parallel techniques for cataloguing the regulome of the human brain
Complex brain disorders are highly heritable and arise from a complex polygenic risk
architecture. Many disease-associated loci are found in non-coding regions that house …
architecture. Many disease-associated loci are found in non-coding regions that house …