Development and validation of a novel criterion of histologic healing in ulcerative colitis defined by inflammatory cell enumeration in lamina propria mucosae: A …
H Gao, K Peng, Y Shi, S Zhu, R Sun, C Xu… - Chinese Medical …, 2024 - journals.lww.com
Background: Histological healing is closely associated with improved long-term clinical
outcomes and lowered relapses in patients with ulcerative colitis (UC). Here, we developed …
outcomes and lowered relapses in patients with ulcerative colitis (UC). Here, we developed …
[HTML][HTML] Susceptibility gene profiling elucidates the pathogenesis of inflammatory bowel disease and provides precision medicine
H Gao, R Liu, H Huang, Z Liu - Clinical and Translational Medicine, 2023 - ncbi.nlm.nih.gov
Inflammatory bowel diseases (IBD) are characterized by idiopathic chronic inflammation of
the gastrointestinal tract, comprising the two major entities ulcerative colitis (UC) and …
the gastrointestinal tract, comprising the two major entities ulcerative colitis (UC) and …
Single-cell RNA sequencing reveals dysregulated cellular programmes in the inflamed epithelium of Crohn's disease patients.
Crohn's disease (CD) is a complex inflammatory disorder of incompletely understood
molecular aetiology. We generated a large single-cell RNA sequencing dataset from the …
molecular aetiology. We generated a large single-cell RNA sequencing dataset from the …
Regulatory Variants on the Leukocyte Immunoglobulin-Like Receptor Gene Cluster are Associated with Crohn's Disease and Interact with Regulatory Variants for …
K Kim, SJ Oh, J Lee, A Kwon, CY Yu… - Journal of Crohn's …, 2024 - academic.oup.com
Abstract Background and Aims Crohn's disease [CD] has a complex polygenic aetiology
with high heritability. There is ongoing effort to identify novel variants associated with …
with high heritability. There is ongoing effort to identify novel variants associated with …
A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology Spectra
There is considerable comorbidity across externalizing and internalizing behavior
dimensions of psychopathology. We applied genomic structural equation modeling (gSEM) …
dimensions of psychopathology. We applied genomic structural equation modeling (gSEM) …
Refining the Concept of Microscopic Colitis: HLA Signatures Discriminating Collagenous and Lymphocytic Colitis
SBU Jordi, B Misselwitz - Journal of Crohn's and Colitis, 2024 - academic.oup.com
Inflammatory bowel diseases [IBD] are complex diseases whose aetiopathogenesis has not
been entirely clarified despite many years of intensive research efforts. A growing body of …
been entirely clarified despite many years of intensive research efforts. A growing body of …
The latest breakthrough on genetic characteristics of inflammatory bowel disease in Chinese and other East Asian ancestries
H Gao, Z Liu - Precision Clinical Medicine, 2023 - academic.oup.com
Inflammatory bowel diseases (IBDs) are complex chronic disorders of the gastrointestinal
tract with the following two subtypes: Crohn's disease and ulcerative colitis. Disease …
tract with the following two subtypes: Crohn's disease and ulcerative colitis. Disease …
Familial coaggregation of inflammatory bowel disease with cardiovascular disease: a nationwide multigenerational cohort study
With great interest, we read the article by Leibovitzh et al, 1 in which the authors identified 25
proteins as novel biomarkers for Crohn's disease (CD) in first-degree relatives (FDRs) of …
proteins as novel biomarkers for Crohn's disease (CD) in first-degree relatives (FDRs) of …
Exclusive Enteral Nutrition Initiates Individual Protective Microbiome Changes to Induce Remission in Pediatric Crohn's Disease
Exclusive enteral nutrition (EEN) is the first-line therapy for pediatric Crohn's disease (CD),
but protective mechanisms remain unknown. We established a prospective pediatric cohort …
but protective mechanisms remain unknown. We established a prospective pediatric cohort …
Accessible chromatin maps of inflammatory bowel disease intestine nominate cell-type mediators of genetic disease risk
JA Wayman, Z Yang, E Angerman, E Bonkowski… - bioRxiv, 2024 - biorxiv.org
Inflammatory Bowel Disease (IBD) is a chronic and often debilitating autoinflammatory
condition, with an increasing incidence in children. Standard-of-care therapies lead to …
condition, with an increasing incidence in children. Standard-of-care therapies lead to …