Chromosome conformation elucidates regulatory relationships in developing human brain
Three-dimensional physical interactions within chromosomes dynamically regulate gene
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
AF Pardiñas, P Holmans, AJ Pocklington… - Nature …, 2018 - nature.com
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia
By analyzing the exomes of 12,332 unrelated Swedish individuals, including 4,877
individuals affected with schizophrenia, in ways informed by exome sequences from 45,376 …
individuals affected with schizophrenia, in ways informed by exome sequences from 45,376 …
Boosting the power of schizophrenia genetics by leveraging new statistical tools
OA Andreassen, WK Thompson… - Schizophrenia …, 2014 - academic.oup.com
Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …
associated with schizophrenia, but these variants explain only a small portion of the …
Genome-wide expression profiling of schizophrenia using a large combined cohort
Numerous studies have examined gene expression profiles in post-mortem human brain
samples from individuals with schizophrenia compared with healthy controls, to gain insight …
samples from individuals with schizophrenia compared with healthy controls, to gain insight …
Diverse types of genetic variation converge on functional gene networks involved in schizophrenia
Despite the successful identification of several relevant genomic loci, the underlying
molecular mechanisms of schizophrenia remain largely unclear. We developed a …
molecular mechanisms of schizophrenia remain largely unclear. We developed a …
[PDF][PDF] Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions
Genomic studies have identified hundreds of candidate genes near loci associated with risk
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
Schizophrenia is a complex disorder caused by both genetic and environmental factors.
Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the …
Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the …
Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study
ABSTRACT The Consortium on the Genetics of Schizophrenia Family Study (COGS-1) has
previously reported our efforts to characterize the genetic architecture of 12 primary …
previously reported our efforts to characterize the genetic architecture of 12 primary …