Background While hybridization based analysis of the cortical transcriptome has provided
important insight into the neuropathology of schizophrenia, it represents a restricted view of …

Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …

Schizophrenia is a devastating, highly heritable brain disorder of unknown etiology.
Recently, the first common genetic variant associated on a genome-wide level with …

Given that the genetic risk for schizophrenia is highly polygenic and the effect sizes, even for
rare or de novo events, are modest at best, it has been suggested that multiple biological …

Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …

Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a
population prevalence of∼ 1%. Previous studies have implicated synaptic dysfunction in …

We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the
association between the disorder and chromosomal copy number (CNV) burden. We …

Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …

The most significant common variant association for schizophrenia (SCZ) reflects increased
expression of the complement component 4A (C4A). Yet, it remains unclear how C4A …

After decades of halting progress, recent large genome-wide association studies (GWAS)
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …