[HTML][HTML] Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
Molecular characterization of the individual cell types in human kidney as well as model
organisms are critical in defining organ function and understanding translational aspects of …
organisms are critical in defining organ function and understanding translational aspects of …
Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing
Recent advances in single-cell sequencing provide a unique opportunity to gain novel
insights into the diversity, lineage, and functions of cell types constituting a tissue/organ …
insights into the diversity, lineage, and functions of cell types constituting a tissue/organ …
[HTML][HTML] Organoid single cell profiling identifies a transcriptional signature of glomerular disease
Podocyte injury is central to many forms of kidney disease, but transcriptional signatures
reflecting podocyte injury and compensation mechanisms are challenging to analyze in vivo …
reflecting podocyte injury and compensation mechanisms are challenging to analyze in vivo …
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …
dysfunction is poorly understood. In the present study, we define the genetic association with …
Defining cell-type specificity at the transcriptional level in human disease
W Ju, CS Greene, F Eichinger, V Nair… - Genome …, 2013 - genome.cshlp.org
Cell-lineage–specific transcripts are essential for differentiated tissue function, implicated in
hereditary organ failure, and mediate acquired chronic diseases. However, experimental …
hereditary organ failure, and mediate acquired chronic diseases. However, experimental …
[PDF][PDF] Progressive recruitment of mesenchymal progenitors reveals a time-dependent process of cell fate acquisition in mouse and human nephrogenesis
Mammalian nephrons arise from a limited nephron progenitor pool through a reiterative
inductive process extending over days (mouse) or weeks (human) of kidney development …
inductive process extending over days (mouse) or weeks (human) of kidney development …
Single-cell transcriptome profiling of the kidney glomerulus identifies key cell types and reactions to injury
JJ Chung, L Goldstein, YJJ Chen, J Lee… - Journal of the …, 2020 - journals.lww.com
Background The glomerulus is a specialized capillary bed that is involved in urine
production and BP control. Glomerular injury is a major cause of CKD, which is epidemic …
production and BP control. Glomerular injury is a major cause of CKD, which is epidemic …
Coordinating early kidney development: lessons from gene targeting
S Vainio, Y Lin - Nature Reviews Genetics, 2002 - nature.com
The kidney is widely used to study the mechanisms of organogenesis. Its development
involves fundamental processes, such as epithelial branching, induced morphogenesis and …
involves fundamental processes, such as epithelial branching, induced morphogenesis and …
Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis
During mouse embryonic development, pluripotent cells rapidly divide and diversify, yet the
regulatory programs that define the cell repertoire for each organ remain ill-defined. To …
regulatory programs that define the cell repertoire for each organ remain ill-defined. To …
[PDF][PDF] The nuclear receptor ESRRA protects from kidney disease by coupling metabolism and differentiation
Kidney disease is poorly understood because of the organ's cellular diversity. We used
single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular …
single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular …