Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …

Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate
(eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to …

Epigenetics refers to a heritable change in the pattern of gene expression that is mediated
by a mechanism specifically not due to alterations in the primary nucleotide sequence. Well …

Background One in eleven people is affected by chronic kidney disease, a condition
characterized by kidney fibrosis and progressive loss of kidney function. Epidemiological …

There is a need to define regions of gene activation or repression that control human kidney
cells in states of health, injury, and repair to understand the molecular pathogenesis of …

The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

Chronic kidney disease affects 10% of the population with notable differences in ethnic and
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …

The integration of single cell transcriptome and chromatin accessibility datasets enables a
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …

Background Three different cell types constitute the glomerular filter: mesangial cells,
endothelial cells, and podocytes. However, to what extent cellular heterogeneity exists …

Expression quantitative trait loci (eQTL) studies illuminate the genetics of gene expression
and, in disease research, can be particularly illuminating when using the tissues directly …