Genome-wide association studies (GWAS) have identified loci for kidney disease, but the
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …

Lupus nephritis (LN) is a common manifestation of systemic lupus erythematosus that can
lead to irreversible renal impairment. Although the prognosis of LN has improved …

Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Background The aim of this study was to assess the associations of modifiable lifestyle
factors (smoking, coffee consumption, sleep, and physical activity) and cardiometabolic …

International Journal of Epidemiology, 2023, e66–e79 https://doi. org/10.1093/ije/dyac114
Advance Access Publication Date: 28 May 2022 Cohort Profile comprehensive molecular …

Background Studies have found sleeping behaviors, such as sleep duration, to be
associated with kidney function and cardiovascular disease risk. However, whether short or …

Understanding the genetic architecture of host proteins interacting with SARS-CoV-2 or
mediating the maladaptive host response to COVID-19 can help to identify new or repurpose …

Chronic kidney disease (CKD) is highly prevalent in the elderly population. However, it is
rarely investigated whether kidney function is causally linked to biological aging itself. In this …

Exposure to stressful life events increases the risk for psychiatric disorders. Mechanistic
insight into the genetic factors moderating the impact of stress can increase our …

Shear stress generated by urinary fluid flow is an important regulator of renal function. Its
dysregulation is observed in various chronic and acute kidney diseases. Previously, we …