Addressing the ethical and societal challenges posed by genome-wide association studies of behavioral and brain-related traits

MC de Hemptinne, D Posthuma - Nature neuroscience, 2023 - nature.com
Genome-wide association studies have led to the identification of robust statistical
associations of genetic variants with numerous brain-related traits, including neurological …

[HTML][HTML] Integrated genomic selection for accelerating breeding programs of climate-smart cereals

D Sinha, AK Maurya, G Abdi, M Majeed, R Agarwal… - Genes, 2023 - mdpi.com
Rapidly rising population and climate changes are two critical issues that require immediate
action to achieve sustainable development goals. The rising population is posing increased …

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies

M Camilleri, A Zhernakova, I Bozzarelli… - Nature Reviews …, 2022 - nature.com
The pathophysiology of irritable bowel syndrome (IBS) is multifactorial and probably
involves genetic predisposition and the effect of environmental factors. Unlike other …

[PDF][PDF] Addressing the challenges of polygenic scores in human genetic research

J Novembre, C Stein, S Asgari… - The American Journal of …, 2022 - cell.com
The genotyping of millions of human samples has made it possible to evaluate variants
across the human genome for their possible association with risks for numerous diseases …

Examining the shared etiology of psychopathology with genome-wide association studies

TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …

[HTML][HTML] Immuno-modulatory effects of intervertebral disc cells

P Bermudez-Lekerika, KB Crump… - Frontiers in cell and …, 2022 - frontiersin.org
Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …

Characterizing the shared genetic underpinnings of schizophrenia and cardiovascular disease risk factors

L Rødevand, Z Rahman, GFL Hindley… - American Journal of …, 2023 - Am Psychiatric Assoc
Objective: Schizophrenia is associated with increased risk of cardiovascular disease (CVD),
although there is variation in risk among individuals. There are indications of shared genetic …

Addressing the challenge of biomedical data inequality: An artificial intelligence perspective

Y Gao, T Sharma, Y Cui - Annual review of biomedical data …, 2023 - annualreviews.org
Artificial intelligence (AI) and other data-driven technologies hold great promise to transform
healthcare and confer the predictive power essential to precision medicine. However, the …

[HTML][HTML] Genome-wide association study of leaf-related traits in tea plant in Guizhou based on genotyping-by-sequencing

Y Chen, S Niu, X Deng, Q Song, L He, D Bai, Y He - BMC Plant Biology, 2023 - Springer
Background Studying the genetic characteristics of tea plant (Camellia spp.) leaf traits is
essential for improving yield and quality through breeding and selection. Guizhou Plateau …

[HTML][HTML] Behaviour genetics and sleep: A narrative review of the last decade of quantitative and molecular genetic research in humans

JJ Madrid-Valero, AM Gregory - Sleep Medicine Reviews, 2023 - Elsevier
During the last decade quantitative and molecular genetic research on sleep has increased
considerably. New behavioural genetics techniques have marked a new era for sleep …