Patients with schizophrenia have consistently shown brain volumetric abnormalities,
implicating both etiological and pathological processes. However, the genetic relationship …

African populations are vastly underrepresented in genetic studies but have the most
genetic variation and face wide-ranging environmental exposures globally. Because …

Given the many small-effect loci uncovered by genome-wide association studies (GWAS),
polygenic scores have become central to genomic medicine, and have found application in …

Background A large proportion of pulmonary embolism (PE) heritability remains
unexplained, particularly among the East Asian (EAS) population. Our study aims to expand …

Schizophrenia is a complex and often chronic psychiatric disorder with high heritability.
Diagnosis of schizophrenia is still made clinically based on psychiatric symptoms; no …

Background The relationship between psychotic disorders and cannabis use is heavily
debated. Shared underlying genetic risk is one potential explanation. We investigated the …

Neuropsychiatric disorders, such as autism spectrum disorder (ASD), attention deficit
hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major …

Background Schizophrenia (SCZ) and bipolar disorder (BIP) are debilitating
neuropsychiatric disorders, collectively affecting 2% of the world's population. Recognizing …

Despite strong transethnic genetic correlations reported in the literature for many complex
traits, the non-transferability of polygenic risk scores across populations suggests the …

Importance The genetic basis of bipolar disorder (BD) in Han Chinese individuals is not fully
understood. Objective To explore the genetic basis of BD in the Han Chinese population …