Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity
Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent
morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 …
morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 …
[HTML][HTML] Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease
J Lake, C Warly Solsberg, JJ Kim, J Acosta-Uribe… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …
out in European ancestry individuals despite the known variation in genetic architecture and …
[HTML][HTML] Meta-analyses identify DNA methylation associated with kidney function and damage
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
[HTML][HTML] High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease
Aims/hypothesis Type 2 diabetes is highly polygenic and influenced by multiple biological
pathways. Rapid expansion in the number of type 2 diabetes loci can be leveraged to …
pathways. Rapid expansion in the number of type 2 diabetes loci can be leveraged to …
[HTML][HTML] Protective role of Nrf2 in renal disease
M Guerrero-Hue, S Rayego-Mateos… - Antioxidants, 2020 - mdpi.com
Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted
to become by 2040 the fifth global cause of death. CKD is characterized by increased …
to become by 2040 the fifth global cause of death. CKD is characterized by increased …
Atrial fibrillation and kidney function: a bidirectional Mendelian randomization study
S Park, S Lee, Y Kim, Y Lee, MW Kang… - European heart …, 2021 - academic.oup.com
Aims The aim of this study was to investigate the causal effects between atrial fibrillation (AF)
and kidney function. Methods and results We performed a bidirectional summary-level …
and kidney function. Methods and results We performed a bidirectional summary-level …
Mild-to-moderate kidney dysfunction and cardiovascular disease: observational and mendelian randomization analyses
Background: End-stage renal disease is associated with a high risk of cardiovascular
events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally …
events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally …
[HTML][HTML] Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies
Abstract Chronic Kidney Disease (CKD) represents a slowly progressive disorder that is
typically silent until late stages, but early intervention can significantly delay its progression …
typically silent until late stages, but early intervention can significantly delay its progression …
[HTML][HTML] Causal effects of gut microbiota on the risk of chronic kidney disease: a Mendelian randomization study
M Luo, J Cai, S Luo, X Hong, L Xu, H Lin… - Frontiers in Cellular …, 2023 - frontiersin.org
Background: Previous studies have reported that gut microbiota is associated with an
increased risk of chronic kidney disease (CKD) progression. However, whether gut …
increased risk of chronic kidney disease (CKD) progression. However, whether gut …
[HTML][HTML] Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is
associated with severe clinical endpoints. In contrast to cross-sectionally assessed …
associated with severe clinical endpoints. In contrast to cross-sectionally assessed …