Increased exonic de novo mutation rate in individuals with schizophrenia
Schizophrenia is a severe psychiatric disorder that profoundly affects cognitive, behavioral
and emotional processes. The wide spectrum of symptoms and clinical variability in …
and emotional processes. The wide spectrum of symptoms and clinical variability in …
Common variants on chromosome 6p22. 1 are associated with schizophrenia
Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5–1%, with high
heritability (80–85%) and complex transmission. Recent studies implicate rare, large, high …
heritability (80–85%) and complex transmission. Recent studies implicate rare, large, high …
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11. 2
To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide
association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 …
association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 …
De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia
Schizophrenia is a highly polygenic disorder with important contributions from both common
and rare risk alleles. We analyzed exome sequencing data for de novo variants (DNVs) in a …
and rare risk alleles. We analyzed exome sequencing data for de novo variants (DNVs) in a …
Whole genome sequencing in psychiatric disorders: the WGSPD consortium
As technology advances, whole genome sequencing (WGS) is likely to supersede other
genotyping technologies. The rate of this change depends on its relative cost and utility …
genotyping technologies. The rate of this change depends on its relative cost and utility …
The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability
By performing a meta-analysis of rare coding variants in whole-exome sequences from
4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and …
4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and …
A neuroimaging biomarker for striatal dysfunction in schizophrenia
Mounting evidence suggests that function and connectivity of the striatum is disrupted in
schizophrenia,,,–. We have developed a new hypothesis-driven neuroimaging biomarker for …
schizophrenia,,,–. We have developed a new hypothesis-driven neuroimaging biomarker for …
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Transcriptomic imputation approaches combine eQTL reference panels with large-scale
genotype data in order to test associations between disease and gene expression. These …
genotype data in order to test associations between disease and gene expression. These …
WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior
WebQTL. The abundance of Grin2b mRNA transcript in several forebrain data sets varies
approximately two-fold across 35 strains. Half of the variation in expression is heritable; and …
approximately two-fold across 35 strains. Half of the variation in expression is heritable; and …
Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia
By meta-analyzing the whole-exomes of 24,248 cases and 97,322 controls, we implicate
ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for …
ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for …