Genome-wide association studies (GWAS) have identified more than 100 loci that show
robust association with schizophrenia risk. However, due to the complexity of linkage …

Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …

Genes disrupted in schizophrenia may be revealed by de novo mutations in affected
persons from otherwise healthy families. Furthermore, during normal brain development …

Most studies of gene expression in the brains of individuals with schizophrenia have
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …

Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …

Schizophrenia is a highly polygenic brain disorder. The main hypothesis for disease etiology
in schizophrenia primarily focuses on the role of dysfunctional synaptic transmission …

Identifying the genetic underpinnings of complex diseases offers insight into the etiological
mechanisms leading to manifestation of the disease. New and more effective treatments for …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Schizophrenia genome-wide association studies (GWAS) have identified common SNPs,
rare copy number variants (CNVs) and a large polygenic contribution to illness risk, but …

We outline an ambitious project to characterize the genetic and epigenetic regulation of
multiple facets of transcription in distinct brain regions across the human lifespan in samples …