In the second half of the twentieth century, twin and family studies established beyond a
reasonable doubt that all forms of psychopathology are substantially heritable and highly …

To understand the role of environment in the pathoetiology of psychosis spectrum disorders,
research has thus far mainly investigated the effects of single exposures in isolation, such as …

The complexity of autism's phenotypic spectra is well-known, yet most genetic research uses
case-control status as the target trait. It is undetermined if autistic symptom domain severity …

Background Schizophrenia (SCZ) is a heterogeneous neuropsychiatric disorder for which
current treatment has insufficient efficacy and severe adverse effects. The modifiable gut …

Cognitive deficits are core symptoms of schizophrenia but remain poorly addressed by
dopamine-based antipsychotic medications. Glutamate abnormalities are implicated in …

Schizophrenia (SZ) and bipolar disorder (BP) are highly heritable major psychiatric
disorders that share a substantial portion of genetic risk as well as their clinical …

Despite advances in identifying rare and common genetic variants conferring risk for ADHD,
the lack of a transcriptomic understanding of cortico-striatal brain circuitry has stymied a …

The clinically heterogeneous presentation of schizophrenia is compounded by the
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …

BackgroundHospital-based biobanks are being increasingly considered as a resource for
translating polygenic risk scores (PRS) into clinical practice. However, since these biobanks …

Prenatal exposure to the anti-seizure medication sodium valproate (VPA) is associated with
an increased risk of adverse postnatal neurodevelopmental outcomes, including lowered …