Genetics is of the essence to face NAFLD
Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease
worldwide. It is closely related to obesity, insulin resistance (IR) and dyslipidemia so much …
worldwide. It is closely related to obesity, insulin resistance (IR) and dyslipidemia so much …
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Polygenic risk scores (PRSs) have improved in predictive performance, but several
challenges remain to be addressed before PRSs can be implemented in the clinic, including …
challenges remain to be addressed before PRSs can be implemented in the clinic, including …
Working memory and reaction time variability mediate the relationship between polygenic risk and ADHD traits in a general population sample
Endophenotypes are heritable and quantifiable traits indexing genetic liability for a disorder.
Here, we examined three potential endophenotypes, working memory function, response …
Here, we examined three potential endophenotypes, working memory function, response …
Dissecting autism and schizophrenia through neuroimaging genomics
Neuroimaging genomic studies of autism spectrum disorder and schizophrenia have mainly
adopted a 'top-down'approach, beginning with the behavioural diagnosis, and moving down …
adopted a 'top-down'approach, beginning with the behavioural diagnosis, and moving down …
The genetic architecture of schizophrenia: review of large-scale genetic studies
H Kato, H Kimura, I Kushima, N Takahashi… - Journal of Human …, 2023 - nature.com
Schizophrenia is a complex and often chronic psychiatric disorder with high heritability.
Diagnosis of schizophrenia is still made clinically based on psychiatric symptoms; no …
Diagnosis of schizophrenia is still made clinically based on psychiatric symptoms; no …
Polygenic risk scores in Alzheimer's disease genetics: methodology, applications, inclusion, and diversity
The success of genome-wide association studies (GWAS) completed in the last 15 years
has reinforced a key fact: polygenic architecture makes a substantial contribution to variation …
has reinforced a key fact: polygenic architecture makes a substantial contribution to variation …
Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa
Background Genome-wide association studies do not always replicate well across
populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher …
populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher …
Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations
Background The genetic architectures of colorectal cancer are distinct across different
populations. To date, the majority of polygenic risk scores (PRSs) are derived from …
populations. To date, the majority of polygenic risk scores (PRSs) are derived from …
Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype?
Over the last years, the decreased costs and enhanced accessibility to large genome-wide
association studies datasets have laid the foundations for the development of polygenic risk …
association studies datasets have laid the foundations for the development of polygenic risk …
Harnessing the potential of machine learning and artificial intelligence for dementia research
Progress in dementia research has been limited, with substantial gaps in our knowledge of
targets for prevention, mechanisms for disease progression, and disease-modifying …
targets for prevention, mechanisms for disease progression, and disease-modifying …