Prospective study design and data analysis in UK Biobank
NE Allen, B Lacey, DA Lawlor, JP Pell… - Science Translational …, 2024 - science.org
Population-based prospective studies, such as UK Biobank, are valuable for generating and
testing hypotheses about the potential causes of human disease. We describe how UK …
testing hypotheses about the potential causes of human disease. We describe how UK …
RNA‐binding proteins in autoimmunity: From genetics to molecular biology
V Lodde, M Floris, E Zoroddu… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Autoimmune diseases (ADs) are chronic pathologies generated by the loss of immune
tolerance to the body's own cells and tissues. There is growing recognition that RNA …
tolerance to the body's own cells and tissues. There is growing recognition that RNA …
PROBER identifies proteins associated with programmable sequence-specific DNA in living cells
DNA–protein interactions mediate physiologic gene regulation and may be altered by DNA
variants linked to polygenic disease. To enhance the speed and signal-to-noise ratio (SNR) …
variants linked to polygenic disease. To enhance the speed and signal-to-noise ratio (SNR) …
[PDF][PDF] Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes
MA Nieves-Colón, KMB Rivera, K Sandoval… - The American Journal of …, 2022 - cell.com
Preeclampsia is a multi-organ complication of pregnancy characterized by sudden
hypertension and proteinuria that is among the leading causes of preterm delivery and …
hypertension and proteinuria that is among the leading causes of preterm delivery and …
[HTML][HTML] Two decades of association mapping: Insights on disease resistance in major crops
Climate change across the globe has an impact on the occurrence, prevalence, and severity
of plant diseases. About 30% of yield losses in major crops are due to plant diseases; …
of plant diseases. About 30% of yield losses in major crops are due to plant diseases; …
Toward identification of functional sequences and variants in noncoding DNA
Understanding the noncoding part of the genome, which encodes gene regulation, is
necessary to identify genetic mechanisms of disease and translate findings from genome …
necessary to identify genetic mechanisms of disease and translate findings from genome …
Graph convolutional network-based feature selection for high-dimensional and low-sample size data
Motivation Feature selection is a powerful dimension reduction technique which selects a
subset of relevant features for model construction. Numerous feature selection methods …
subset of relevant features for model construction. Numerous feature selection methods …
[HTML][HTML] Invited review: Good practices in genome-wide association studies to identify candidate sequence variants in dairy cattle
Genotype data from dairy cattle selection programs have greatly facilitated GWAS to identify
variants related to economic traits. Results can enhance the accuracy of genomic prediction …
variants related to economic traits. Results can enhance the accuracy of genomic prediction …
[HTML][HTML] Genome-wide association study of COVID-19 outcomes reveals novel host genetic risk loci in the Serbian population
Host genetics, an important contributor to the COVID-19 clinical susceptibility and severity,
currently is the focus of multiple genome-wide association studies (GWAS) in populations …
currently is the focus of multiple genome-wide association studies (GWAS) in populations …
How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …
scientific and medical advances, clinically effective regenerative therapies including stem …