A large portion of common variant loci associated with genetic risk for schizophrenia reside
within noncoding sequence of unknown function. Here, we demonstrate promoter and …

Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …

Translating a set of disease regions into insight about pathogenic mechanisms requires not
only the ability to identify the key disease genes within them, but also the biological …

Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …

Importance The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …

Recent studies into the etiology of schizophrenia have yielded both promising leads and
disappointing dead ends, indicating the multifactored and complex nature of the disorder …

Highlights•The genetic liability of schizophrenia is established as polygenic.•Schizophrenia
risk alleles converge onto specific synaptic gene-sets.•Schizophrenia shares risk alleles with …

How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …

Africa, the ancestral home of all modern humans, is the most informative continent for
understanding the human genome and its contribution to complex disease. To better …

Recent genomic studies have revealed the highly polygenic nature of psychiatric disorders,
including schizophrenia, bipolar disorder and major depressive disorder. Many of the …