Comparative genetic architectures of schizophrenia in East Asian and European populations
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …
globally. Large-scale schizophrenia genetic studies have reported primarily on European …
[HTML][HTML] Synaptic and gene regulatory mechanisms in schizophrenia, autism, and 22q11. 2 copy number variant–mediated risk for neuropsychiatric disorders
Abstract Background 22q11. 2 copy number variants are among the most highly penetrant
genetic risk variants for developmental neuropsychiatric disorders such as schizophrenia …
genetic risk variants for developmental neuropsychiatric disorders such as schizophrenia …
Functional connectome-wide associations of schizophrenia polygenic risk
Schizophrenia is a highly heritable mental disorder characterized by functional
dysconnectivity across the brain. However, the relationships between polygenic risk factors …
dysconnectivity across the brain. However, the relationships between polygenic risk factors …
Single-cell dissection of schizophrenia reveals neurodevelopmental-synaptic link and transcriptional resilience associated cellular state
B Ruzicka, S Mohammadi… - Biological …, 2021 - biologicalpsychiatryjournal.com
Background Schizophrenia is a severe mental illness afflicting young adults just as they
approach their full potential, often resulting in a lifetime of severe disability. While many …
approach their full potential, often resulting in a lifetime of severe disability. While many …
[HTML][HTML] Genetics of schizophrenia
Highlights•The genetic liability of schizophrenia is established as polygenic.•Schizophrenia
risk alleles converge onto specific synaptic gene-sets.•Schizophrenia shares risk alleles with …
risk alleles converge onto specific synaptic gene-sets.•Schizophrenia shares risk alleles with …
Genomic findings in schizophrenia and their implications
There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia
Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk
Specific cell populations may have unique contributions to schizophrenia but may be missed
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …
Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
CP Yang, X Li, Y Wu, Q Shen, Y Zeng, Q Xiong… - Nature …, 2018 - nature.com
Recent genome-wide association studies (GWAS) have identified multiple risk loci that show
strong associations with schizophrenia. However, pinpointing the potential causal genes at …
strong associations with schizophrenia. However, pinpointing the potential causal genes at …
Epigenetic mechanisms in schizophrenia
S Akbarian - Dialogues in clinical neuroscience, 2014 - Taylor & Francis
Schizophrenia is a major psychiatric disorder that lacks a unifying neuropathology, while
currently available pharmacological treatments provide only limited benefits to many …
currently available pharmacological treatments provide only limited benefits to many …