Background The repertoire of protein expression along the renal tubule depends both on
regulation of transcription and regulation of alternative splicing that can generate multiple …

The kidneys operate at the interface of plasma and urine by clearing molecular waste
products while retaining valuable solutes. Genetic studies of paired plasma and urine …

Comprehensive sequencing of human cancers has identified recurrent mutations in genes
encoding chromatin regulatory proteins. For clear cell renal cell carcinoma (ccRCC), three of …

In patients with diabetes mellitus, poor metabolic control has a long-lasting impact on kidney
disease development. Epigenetic changes, including cytosine methylation, have been …

We identified potential epigenetic biomarkers for chronic kidney disease progression by
comparing site-specific DNA methylation levels in more than 14,000 genes between African …

Progression of chronic kidney disease remains a principal problem in clinical nephrology
and there is a pressing need for novel therapeutics and biomarkers. Aberrant promoter CpG …

Molecular characterization of the individual cell types in human kidney as well as model
organisms are critical in defining organ function and understanding translational aspects of …

Background Proximal tubule cells dominate the kidney parenchyma numerically, although
less abundant cell types of the distal nephron have disproportionate roles in water and …

Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Diabetic vascular
complications such as DN can progress despite subsequent glycemic control, suggesting a …

Kidney stone disease is a common condition. To search for sequence variants conferring
risk of kidney stones, we conducted a genome-wide association study in 3,773 cases and …