Genetic kidney diseases as an underrecognized cause of chronic kidney disease: the key role of international registry reports
Inherited kidney diseases (IKDs) are among the leading causes of early-onset chronic
kidney disease (CKD) and are responsible for at least 10–15% of cases of kidney …
kidney disease (CKD) and are responsible for at least 10–15% of cases of kidney …
[PDF][PDF] Spatial transcriptional mapping of the human nephrogenic program
NO Lindström, R Sealfon, X Chen, RK Parvez… - Developmental cell, 2021 - cell.com
Congenital abnormalities of the kidney and urinary tract are among the most common birth
defects, affecting 3% of newborns. The human kidney forms around a million nephrons from …
defects, affecting 3% of newborns. The human kidney forms around a million nephrons from …
An intermediate-effect size variant in UMOD confers risk for chronic kidney disease
The kidney-specific gene UMOD encodes for uromodulin, the most abundant protein
excreted in normal urine. Rare large-effect variants in UMOD cause autosomal dominant …
excreted in normal urine. Rare large-effect variants in UMOD cause autosomal dominant …
Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney
Aims Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute
respiratory syndrome coronavirus (SARS-CoV-2)—the cause of coronavirus disease 2019 …
respiratory syndrome coronavirus (SARS-CoV-2)—the cause of coronavirus disease 2019 …
[HTML][HTML] Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development
Epigenetic changes may fill a critical gap in our understanding of kidney disease
development, as they not only reflect metabolic changes but are also preserved and …
development, as they not only reflect metabolic changes but are also preserved and …
Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation
Background Sex hormone-binding globulin (SHBG), testosterone and oestradiol have been
associated with many diseases in observational studies; however, the causality of …
associated with many diseases in observational studies; however, the causality of …
[HTML][HTML] Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture
X Hao, Z Shao, N Zhang, M Jiang, X Cao, S Li… - Nature …, 2023 - nature.com
Kidney stone disease (KSD) is a complex disorder with high heritability and prevalence. We
performed a large genome-wide association study (GWAS) meta-analysis for KSD to date …
performed a large genome-wide association study (GWAS) meta-analysis for KSD to date …
[HTML][HTML] Genetically predicted education attainment in relation to somatic and mental health
A deeper understanding of the causal links from education level to health outcomes may
shed a light for disease prevention. In the present Mendelian randomization study, we found …
shed a light for disease prevention. In the present Mendelian randomization study, we found …
[HTML][HTML] Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank
M Wuttke, E König, MA Katsara, H Kirsten… - Nature …, 2023 - nature.com
Genome-wide association studies have discovered hundreds of associations between
common genotypes and kidney function but cannot comprehensively investigate rare coding …
common genotypes and kidney function but cannot comprehensively investigate rare coding …
2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …