[HTML][HTML] Idiopathic pulmonary fibrosis and the role of genetics in the era of precision medicine

A Alonso-Gonzalez, E Tosco-Herrera… - Frontiers in …, 2023 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic, rare progressive lung disease, characterized
by lung scarring and the irreversible loss of lung function. Two anti-fibrotic drugs, nintedanib …

[PDF][PDF] FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

N Wieder, JC Fried, C Kim, EH Sidhom, MR Brown… - Cell metabolism, 2023 - cell.com
Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-
associated diseases. However, there are no scalable approaches to comprehensively …

pubmedKB: an interactive web server for exploring biomedical entity relations in the biomedical literature

PH Li, TF Chen, JY Yu, SH Shih, CH Su… - Nucleic Acids …, 2022 - academic.oup.com
With the proliferation of genomic sequence data for biomedical research, the exploration of
human genetic information by domain experts requires a comprehensive interrogation of …

A Genome‐Wide Association Study Meta‐Analysis of Alpha Angle Suggests Cam‐Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults

BG Faber, M Frysz, AE Hartley, R Ebsim… - Arthritis & …, 2023 - Wiley Online Library
Objective To examine the genetic architecture of cam morphology using alpha angle (AA) as
a proxy measure and conduct an AA genome‐wide association study (GWAS) followed by …

[HTML][HTML] Sex differences in the genetic and molecular mechanisms of coronary artery disease

TR Sakkers, M Mokry, M Civelek, J Erdmann… - Atherosclerosis, 2023 - Elsevier
Sex differences in coronary artery disease (CAD) presentation, risk factors and prognosis
have been widely studied. Similarly, studies on atherosclerosis have shown prominent sex …

The Allele Catalog Tool: a web-based interactive tool for allele discovery and analysis

YO Chan, N Dietz, S Zeng, J Wang, S Flint-Garcia… - BMC genomics, 2023 - Springer
Background The advancement of sequencing technologies today has made a plethora of
whole-genome re-sequenced (WGRS) data publicly available. However, research utilizing …

Interplay of environmental, individual and genetic factors in rheumatoid arthritis provocation

M Arleevskaya, E Takha, S Petrov, G Kazarian… - International Journal of …, 2022 - mdpi.com
In this review, we explore systemization of knowledge about the triggering effects of non-
genetic factors in pathogenic mechanisms that contribute to the development of rheumatoid …

A comparative analysis of current phasing and imputation software

A De Marino, AA Mahmoud, M Bose, KO Bircan… - Plos one, 2022 - journals.plos.org
Whole-genome data has become significantly more accessible over the last two decades.
This can largely be attributed to both reduced sequencing costs and imputation models …

[HTML][HTML] New research perspectives on the interplay between genes and environment on executive function development

PM Miguel, MJ Meaney, PP Silveira - Biological Psychiatry, 2023 - Elsevier
Executive functions (EFs) are a set of skills responsible for the cognitive control of emotional
states and behavior as well as for information processing required for learning and memory …

Current progress in understanding schizophrenia using genomics and pluripotent stem cells: A meta-analytical overview

A Choudhary, D Peles, R Nayak, L Mizrahi… - Schizophrenia Research, 2022 - Elsevier
Schizophrenia (SCZ) is a complex, heritable and polygenic neuropsychiatric disease, which
disables the patients as well as decreases their life expectancy and quality of life. Common …